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Drug Interactions between carboplatin and etoposide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

CARBOplatin etoposide

Applies to: carboplatin and etoposide

MONITOR: Coadministration with carboplatin or cisplatin may increase the systemic exposure of etoposide. The exact mechanism of interaction is unknown but may involve inhibition of etoposide metabolism. In one study, the median clearance of etoposide in 14 pediatric patients receiving concomitant therapy with high-dose carboplatin (400 to 700 mg/m2 given on alternate days of etoposide) was substantially lower than values previously reported in either children or adults. Higher etoposide concentrations were significantly associated with longer time to recovery of hematopoietic function. The interaction has also been reported with cisplatin during acute but not chronic administration.

MANAGEMENT: During concomitant therapy with carboplatin or cisplatin, patients should be observed for potentially increased toxicity of etoposide (e.g., myelosuppression, stomatitis, mucositis, alopecia, hepatotoxicity), and the dosage adjusted accordingly as necessary.

References

  1. Relling MV, McLeod HL, Bowman LC, Santana VM "Etoposide pharmacokinetics and pharmacodynamics after acute and chronic exposure to cisplatin." Clin Pharmacol Ther 56 (1994): 503-11
  2. Rodman JH, Murry DJ, Madden T, Santana VM "Altered etoposide pharmacokinetics and time to engraftment in pediatric patients undergoing autologous bone marrow transplantation." J Clin Oncol 12 (1994): 2390-7
  3. McLeod HL "Clinically relevant drug-drug interactions in oncology." Br J Clin Pharmacol 45 (1998): 539-44

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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