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Drug Interactions between capromab pendetide and nilutamide

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

nilutamide capromab pendetide

Applies to: nilutamide and capromab pendetide

GENERALLY AVOID: The effect of surgical and/or medical androgen ablation on the imaging performance of Indium In 111 capromab pendetide has not been evaluated. Preliminary data suggest that hormone ablation may increase expression of Prostate Specific Membrane Antigen (PSMA)--the target of capromab pendetide--and decrease tumor expression of prostate specific antigen (PSA).

MANAGEMENT: Until more data are available, concomitant use of Indium In 111 capromab pendetide in patients treated with androgen ablation therapy is not recommended.

References (1)
  1. (2015) "Product Information. ProstaScint (capromab pendetide)." Aytu Therapeutics, LLC

Drug and food interactions

Moderate

nilutamide food

Applies to: nilutamide

GENERALLY AVOID: Alcohol intolerance has been reported in 5% to 20% of patients following administration of nilutamide in clinical studies. Symptoms include facial flushes, malaise, and hypotension.

MANAGEMENT: Consumption of alcoholic beverages should be avoided in patients who experience alcohol intolerance with nilutamide.

References (2)
  1. (2001) "Product Information. Nilandron (nilutamide)." Hoechst Marion Roussel
  2. Decensi A, Guarneri D, Paoletti MC, Lalanne JM, Merlo F, Boccardo F (1991) "Phase II study of the pure non-steroidal antiandrogen nilutamide in prostatic cancer. Italian Prostatic Cancer Project (PONCAP)." Eur J Cancer, 27, p. 1100-4

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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