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Drug Interactions between capecitabine and Erbitux

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

capecitabine cetuximab

Applies to: capecitabine and Erbitux (cetuximab)

MONITOR: The concomitant use of parenteral fluorouracil or capecitabine with cetuximab may increase the frequency of myocardial ischemia (infarction and congestive heart failure) and palmar-plantar erythrodysesthesia (hand-foot syndrome).

MANAGEMENT: Patients who are receiving combination treatment with cetuximab and other antineoplastic drugs should be monitored for adverse effects.

References (3)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. EMEA. European Medicines Agency (2007) EPARs. European Union Public Assessment Reports. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid
  3. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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