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Drug Interactions between calcium gluconate and digitoxin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

digitoxin calcium gluconate

Applies to: digitoxin and calcium gluconate

GENERALLY AVOID: The administration of parenteral calcium preparations, particularly by rapid IV injection, may precipitate serious cardiac arrhythmias in digitalized patients. The mechanism is probably related to the additive or synergistic inotropic effects of calcium and digitalis glycosides on the myocardium.

MANAGEMENT: Intravenous calcium should preferably not be used in patients receiving digitalis glycosides, or it should be given slowly or in small amounts to avoid high serum calcium concentrations. Patients should be monitored for development of arrhythmias.

References

  1. (2001) "Product Information. Lanoxin (digoxin)." Glaxo Wellcome
  2. (2001) "Product Information. Calcium Gluconate (calcium gluconate)." Fresenius Kabi USA, LLC
  3. (2001) "Product Information. PhosLo (calcium acetate)." Braintree

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Drug and food interactions

Moderate

calcium gluconate food

Applies to: calcium gluconate

ADJUST DOSING INTERVAL: Administration with food may increase the absorption of calcium. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption.

MANAGEMENT: Calcium may be administered with food to increase absorption. Consider withholding calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
  3. Cerner Multum, Inc. "Australian Product Information."
  4. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  5. Mangels AR (2014) "Bone nutrients for vegetarians." Am J Clin Nutr, 100, epub
  6. Davies NT (1979) "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc, 38, p. 121-8
View all 6 references

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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