Can you take Calcipotriene / dimethicone topical with Calcium saccharate?
1 drug interaction and 2 additional warnings found for the following 2 drugs:
- calcipotriene/dimethicone topical
- calcium saccharate
Drug interactions
Moderate drug interactions
Moderate:
calcipotriene topical calcium saccharate
Applies to: calcipotriene / dimethicone topical and calcium saccharate
The medication in calcipotriene topical is absorbed through the skin into the bloodstream and may cause interactions with other medications. Using calcipotriene topical together with calcium saccharate may occasionally cause your blood calcium levels to become too high. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience signs and symptoms that may suggest excessive blood calcium levels such as dizziness, weakness, lethargy, muscle pain, headache, loss of appetite, nausea, vomiting, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Hypercalcemia and Poisoning by Vitamins.
Hypercalcemia
Major:
calcipotriene / dimethicone topical
The calcipotriene topical in calcipotriene / dimethicone topical has a major potential interaction with Hypercalcemia.
The use of calcipotriene topical preparations is contraindicated in patients with demonstrated hypercalcemia or evidence of vitamin D toxicity. Calcipotriene is a synthetic vitamin D3 analog. Systemic absorption of topically applied calcipotriene ranges from less than 1% for the scalp solution to 5% to 6% for the ointment. Calcipotriene has been reported to be 100 to 200 times less potent in its effects on calcium utilization than natural vitamin D, which facilitates the absorption of calcium in the intestine. Transient, rapidly reversible elevation of serum calcium has been reported following the topical administration of calcipotriene. If elevation in serum calcium outside the normal range occurs, treatment should be discontinued until normal calcium levels are restored. Patients should be advised to contact their physician if they experience early symptoms of hypercalcemia such as weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, abdominal cramps, constipation, diarrhea, vertigo, tinnitus, ataxia, exanthema, muscle pain, bone pain, and irritability.
Poisoning by Vitamins
Major:
calcipotriene / dimethicone topical
The calcipotriene topical in calcipotriene / dimethicone topical has a major potential interaction with Poisoning by Vitamins.
The use of calcipotriene topical preparations is contraindicated in patients with demonstrated hypercalcemia or evidence of vitamin D toxicity. Calcipotriene is a synthetic vitamin D3 analog. Systemic absorption of topically applied calcipotriene ranges from less than 1% for the scalp solution to 5% to 6% for the ointment. Calcipotriene has been reported to be 100 to 200 times less potent in its effects on calcium utilization than natural vitamin D, which facilitates the absorption of calcium in the intestine. Transient, rapidly reversible elevation of serum calcium has been reported following the topical administration of calcipotriene. If elevation in serum calcium outside the normal range occurs, treatment should be discontinued until normal calcium levels are restored. Patients should be advised to contact their physician if they experience early symptoms of hypercalcemia such as weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, abdominal cramps, constipation, diarrhea, vertigo, tinnitus, ataxia, exanthema, muscle pain, bone pain, and irritability.
More resources
calcipotriene / dimethicone topical
A total of 74 drugs are known to interact with calcipotriene / dimethicone topical.
- Calcipotriene / dimethicone topical is in the drug class topical antipsoriatics.
- Calcipotriene / dimethicone topical is used to treat Plaque Psoriasis.
calcium saccharate
A total of 90 drugs are known to interact with calcium saccharate.
- Calcium saccharate is in the drug class minerals and electrolytes.
- Calcium saccharate is used to treat Dietary Supplementation.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.