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Can you take Calcipotriene / dimethicone topical with Calcium saccharate?

1 drug interaction and 2 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

calcipotriene topical calcium saccharate

Applies to: calcipotriene / dimethicone topical and calcium saccharate

The medication in calcipotriene topical is absorbed through the skin into the bloodstream and may cause interactions with other medications. Using calcipotriene topical together with calcium saccharate may occasionally cause your blood calcium levels to become too high. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience signs and symptoms that may suggest excessive blood calcium levels such as dizziness, weakness, lethargy, muscle pain, headache, loss of appetite, nausea, vomiting, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease interactions

2 potential interactions Applies to: 2 conditions, including Hypercalcemia and Poisoning by Vitamins.

Hypercalcemia

Major:

calcipotriene / dimethicone topical

The calcipotriene topical in calcipotriene / dimethicone topical has a major potential interaction with Hypercalcemia.

The use of calcipotriene topical preparations is contraindicated in patients with demonstrated hypercalcemia or evidence of vitamin D toxicity. Calcipotriene is a synthetic vitamin D3 analog. Systemic absorption of topically applied calcipotriene ranges from less than 1% for the scalp solution to 5% to 6% for the ointment. Calcipotriene has been reported to be 100 to 200 times less potent in its effects on calcium utilization than natural vitamin D, which facilitates the absorption of calcium in the intestine. Transient, rapidly reversible elevation of serum calcium has been reported following the topical administration of calcipotriene. If elevation in serum calcium outside the normal range occurs, treatment should be discontinued until normal calcium levels are restored. Patients should be advised to contact their physician if they experience early symptoms of hypercalcemia such as weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, abdominal cramps, constipation, diarrhea, vertigo, tinnitus, ataxia, exanthema, muscle pain, bone pain, and irritability.

Poisoning by Vitamins

Major:

calcipotriene / dimethicone topical

The calcipotriene topical in calcipotriene / dimethicone topical has a major potential interaction with Poisoning by Vitamins.

The use of calcipotriene topical preparations is contraindicated in patients with demonstrated hypercalcemia or evidence of vitamin D toxicity. Calcipotriene is a synthetic vitamin D3 analog. Systemic absorption of topically applied calcipotriene ranges from less than 1% for the scalp solution to 5% to 6% for the ointment. Calcipotriene has been reported to be 100 to 200 times less potent in its effects on calcium utilization than natural vitamin D, which facilitates the absorption of calcium in the intestine. Transient, rapidly reversible elevation of serum calcium has been reported following the topical administration of calcipotriene. If elevation in serum calcium outside the normal range occurs, treatment should be discontinued until normal calcium levels are restored. Patients should be advised to contact their physician if they experience early symptoms of hypercalcemia such as weakness, fatigue, somnolence, headache, anorexia, dry mouth, metallic taste, nausea, vomiting, abdominal cramps, constipation, diarrhea, vertigo, tinnitus, ataxia, exanthema, muscle pain, bone pain, and irritability.

More resources

calcipotriene / dimethicone topical

A total of 74 drugs are known to interact with calcipotriene / dimethicone topical.

calcium saccharate

A total of 90 drugs are known to interact with calcium saccharate.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.