Skip to main content

Drug Interactions between Butalbital Compound and Chloracol

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

chloramphenicol butalbital

Applies to: Chloracol (chloramphenicol) and Butalbital Compound (aspirin / butalbital / caffeine)

MONITOR: Barbiturates may increase the hepatic metabolism of chloramphenicol. Serum chloramphenicol levels and effectiveness may be decreased. Coadministration also may enhance the pharmacologic effect of barbiturates. The proposed mechanism is induction of chloramphenicol metabolism by barbiturates and inhibition of barbiturate metabolism by chloramphenicol.

MANAGEMENT: The effectiveness of chloramphenicol should be monitored, and plasma levels should be checked as clinically appropriate. Dosage should be increased as needed. The patient also should be monitored for barbiturate toxicity.

References

  1. Smith AL, Weber A "Pharmacology of chloramphenicol." Pediatr Clin North Am 30 (1983): 209-36
  2. Ambrose PJ "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet 9 (1984): 222-38
  3. Koup JR, Gibaldi M, McNamara P, et al. "Interaction of chloramphenicol with phenytoin and phenobarbital." Clin Pharmacol Ther 24 (1978): 571-5
  4. Kearns GL, Bocchini JA, Brown RD, et al. "Absence of a pharmacokinetic interaction between chloramphenicol and acetaminophen in children." J Pediatr 107 (1985): 134-9
  5. Palmer DL, Despopoulos A, Rael ED "Induction of chloramphenicol metabolism by phenobarbital." Antimicrob Agents Chemother 1 (1972): 112-5
  6. Mulhall A, de Louvois J, Hurley R "The pharmacokinetics of chloramphenicol in the neonate and young infant." J Antimicrob Chemother 12 (1983): 629-39
  7. Krasinski K, Kusmiesz H, Nelson JD "Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital." Pediatr Infect Dis 1 (1982): 232-5
  8. Bloxham RA, Durbin GM, Johnson T, Winterborn MH "Chloramphenicol and phenobarbitone--a drug interaction." Arch Dis Child 54 (1979): 76-7
  9. Cerner Multum, Inc. "Australian Product Information." O 0
View all 9 references

Switch to consumer interaction data

Minor

aspirin caffeine

Applies to: Butalbital Compound (aspirin / butalbital / caffeine) and Butalbital Compound (aspirin / butalbital / caffeine)

One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.

References

  1. Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6

Switch to consumer interaction data

Drug and food interactions

Major

butalbital food

Applies to: Butalbital Compound (aspirin / butalbital / caffeine)

GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.

MANAGEMENT: The combination of ethanol and barbiturates should be avoided.

References

  1. Gupta RC, Kofoed J "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J 94 (1966): 863-5
  2. Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med 51 (1971): 346-51
  3. Saario I, Linnoila M "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh) 38 (1976): 382-92
  4. Stead AH, Moffat AC "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol 2 (1983): 5-14
  5. Seixas FA "Drug/alcohol interactions: avert potential dangers." Geriatrics 34 (1979): 89-102
View all 5 references

Switch to consumer interaction data

Moderate

aspirin food

Applies to: Butalbital Compound (aspirin / butalbital / caffeine)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):

Switch to consumer interaction data

Minor

caffeine food

Applies to: Butalbital Compound (aspirin / butalbital / caffeine)

The effect of grapefruit juice on the pharmacologic activity of caffeine is controversial. One report suggests that grapefruit juice increases the effect of caffeine. The proposed mechanism is inhibition of cytochrome P-450 metabolism of caffeine. However, a well-conducted pharmacokinetic/pharmacodynamic study did not demonstrate this effect. The clinical significance of this potential interaction is unknown.

References

  1. "Grapefruit juice interactions with drugs." Med Lett Drugs Ther 37 (1995): 73-4
  2. Maish WA, Hampton EM, Whitsett TL, Shepard JD, Lovallo WR "Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics." Pharmacotherapy 16 (1996): 1046-52

Switch to consumer interaction data

Minor

aspirin food

Applies to: Butalbital Compound (aspirin / butalbital / caffeine)

One study has reported that coadministration of caffeine and aspirin lead to a 25% increase in the rate of appearance and 17% increase in maximum concentration of salicylate in the plasma. A significantly higher area under the plasma concentration time curve of salicylate was also reported when both drugs were administered together. The exact mechanism of this interaction has not been specified. Physicians and patients should be aware that coadministration of aspirin and caffeine may lead to higher salicylate levels faster.

References

  1. Yoovathaworn KC, Sriwatanakul K, Thithapandha A "Influence of caffeine on aspirin pharmacokinetics." Eur J Drug Metab Pharmacokinet 11 (1986): 71-6

Switch to consumer interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer