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Drug Interactions between Brondelate and Zyloprim

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

allopurinol oxtriphylline

Applies to: Zyloprim (allopurinol) and Brondelate (guaifenesin / oxtriphylline)

Allopurinol may inhibit the metabolism of the xanthines, possibly increasing serum concentrations and the risk of toxicity. This interaction may be more likely to occur with daily allopurinol doses of 600 mg or more. The mechanism is unknown and data from controlled studies have been conflicting. Patients receiving this combination should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References

  1. Upton RA (1991) "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet, 20, p. 135-50
  2. Manfredi RL, Vesell ES (1981) "Inhibition of theophylline metabolism by long-term allopurinol administration." Clin Pharmacol Ther, 29, p. 224
  3. Barry M, Feely J (1990) "Allopurinol influences aminophenazone elimination." Clin Pharmacokinet, 19, p. 167

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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