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Drug Interactions between bromfenac and Fluorac

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

bromfenac diclofenac topical

Applies to: bromfenac and Fluorac (diclofenac / fluorouracil topical)

MONITOR: Nonsteroidal anti-inflammatory drugs may be absorbed systemically following topical administration. Concomitant use with systemic nonsteroidal anti-inflammatory drugs may result in increased adverse effects such as gastrointestinal toxicity (inflammation, bleeding, ulceration, perforation), cardiovascular thrombotic events, hepatotoxicity (liver enzyme elevations), renal toxicity, fluid retention, edema, hypertension, and inhibition of platelet aggregation.

MANAGEMENT: Patients treated with topical preparations of nonsteroidal anti-inflammatory drugs should avoid or limit the use of systemic nonsteroidal anti-inflammatory drugs. Although systemic exposure is generally low following topical administration, absorption may be increased with frequent applications; use of large quantities or over large areas of skin; use on compromised or diseased skin or open wounds; and use of occlusive dressings or heating pads over application areas.

References

  1. "Product Information. Solaraze (diclofenac topical)." Doak Dermatologics Division (2009):

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Drug and food interactions

Moderate

bromfenac food

Applies to: bromfenac

ADJUST DOSE: In-vivo studies have demonstrated that the absorption of bromfenac is greatly reduced if the drug is taken within three and one-half hours following a high fat meal. The concomitant administration of a high fat meal has led to a 75% reduction in peak plasma concentrations and a 60% reduction in total area under the curve. The mechanism has not been described.

MANAGEMENT: An increased dosage of bromfenac (from 25 to 50 mg) may be needed if a high fat meal is consumed. The clinician may want to warn the patient about subtherapeutic analgesic effects if high fat meals are regularly consumed.

References

  1. "Product Information. DurAct (bromfenac)." Wyeth-Ayerst Laboratories PROD

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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