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Drug Interactions between Bristol-Myers Squibb Gallium (67Ga) Citrate and Uceris

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

budesonide gallium citrate Ga-67

Applies to: Uceris (budesonide) and Bristol-Myers Squibb Gallium (67Ga) Citrate (gallium citrate ga-67)

MONITOR: The concomitant use of glucocorticoids may interfere with uptake of gallium citrate Ga-67 by brain tumors or abscesses. In addition, prednisone may cause thymic uptake of Ga-67.

MANAGEMENT: Clinicians should be aware of possible interference with diagnostic tests in patients who are taking these medications.

References

  1. "Product Information. Gallium Citrate Ga-67 (gallium citrate Ga-67)." Bristol-Myers Squibb (2022):

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Drug and food interactions

Moderate

budesonide food

Applies to: Uceris (budesonide)

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations and systemic effects of orally administered budesonide. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. According to the manufacturer, the systemic exposure of oral budesonide approximately doubles after extensive intake of grapefruit juice.

MANAGEMENT: Patients receiving budesonide should avoid the regular consumption of grapefruits and grapefruit juice to prevent undue increases in plasma budesonide levels and systemic effects.

References

  1. "Product Information. Entocort (budesonide)." AstraZeneca Pharma Inc (2001):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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