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Drug Interactions between brincidofovir and smallpox and mpox vaccine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

brincidofovir smallpox and monkeypox vaccine

Applies to: brincidofovir and smallpox and mpox vaccine

MONITOR: Data from animal studies suggest that coadministration at the same time as brincidofovir may reduce the immune response to the live smallpox vaccine (vaccinia virus). The immune response to live-attenuated, non-replicating smallpox vaccine (modified vaccinia virus Ankara) may also be reduced. Potential interactions between brincidofovir and vaccines have not been studied in humans. The clinical impact of this potential interaction is unknown.

MANAGEMENT: The potential for reduced immune response to the live smallpox vaccine and live-attenuated, non-replicating smallpox vaccine should be monitored if coadministered with brincidofovir.

References (1)
  1. (2022) "Product Information. Tembexa (brincidofovir)." Chimerix, Inc.

Drug and food interactions

Moderate

brincidofovir food

Applies to: brincidofovir

ADJUST DOSING INTERVAL: Administration with food decreases the oral bioavailability of brincidofovir. According to the product labeling, administration of brincidofovir tablets with a low-fat meal (approximately 400 calories, 25% of calories from fat) was associated with a reduction in the systemic exposure (AUC) and peak plasma concentration (Cmax) of brincidofovir by 31% and 49%, respectively, compared to administration under fasting. However, no clinically meaningful changes in intracellular concentrations of cidofovir diphosphate were observed. The effect of food on the oral suspension formulation has not been evaluated.

MANAGEMENT: Brincidofovir oral tablets and suspension should be taken on an empty stomach. If necessary, the oral tablets may be taken with a low-fat meal.

References (1)
  1. (2022) "Product Information. Tembexa (brincidofovir)." Chimerix, Inc.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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