Can you take BPO-5 Wash with Isotretinoin?
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- BPO-5 Wash (benzoyl peroxide topical)
- isotretinoin
Drug interactions
Moderate drug interactions
Moderate:
ISOtretinoin benzoyl peroxide topical
Applies to: isotretinoin and BPO-5 Wash (benzoyl peroxide topical)
Using ISOtretinoin together with benzoyl peroxide topical may increase skin irritation. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
ISOtretinoin Alcohol (Ethanol)
Applies to: isotretinoin
Ask your doctor before using ISOtretinoin together with ethanol (alcohol). Do not drink alcohol while you are taking ISOtretinoin. You may have unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Check your food and medicine labels to be sure these products do not contain alcohol. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
9 potential interactions Applies to: 9 conditions, including High Cholesterol, Depression, Weight Loss, Osteoporosis, and Psychosis.
Alcoholism
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with Alcoholism.
The use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.
Depression
Major:
isotretinoin
ISOtretinoin has a major potential interaction with Depression.
The use of retinoids, primarily isotretinoin, has been associated with causing depression, psychosis and rarely, suicidal ideation. Therapy with retinoids should be administered cautiously in patients with preexisting psychiatric conditions or depression. In addition to withdrawal of therapy, evaluation and follow-up may be necessary in affected patients.
Diabetes Mellitus
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with Diabetes Mellitus.
The use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.
High Cholesterol
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with High Cholesterol.
The use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.
Liver Disease
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with Liver Disease.
The use of retinoids has been associated with elevations in liver enzymes and toxic hepatitis. Therapy with retinoids should be administered cautiously in patients with liver disease. Monitoring liver enzymes is recommended in these patients.
Osteoporosis
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with Osteoporosis.
Isotretinoin may have a negative effect on bone mineral density in some patients. Clinical trials have shown BMD declines in adolescents during a 20 week treatment. Therefore, physicians should use caution when prescribing isotretinoin in patients with a history of childhood osteoporosis, osteomalacia, or other disorders of bone metabolism.
Pseudotumor Cerebri
Major:
isotretinoin
ISOtretinoin has a major potential interaction with Pseudotumor Cerebri.
The use of retinoids has been associated with cases of pseudotumor cerebri (benign intracranial hypertension). Early signs and symptoms include papilledema, headache, nausea and vomiting, and visual disturbances. Patients who experience symptoms of this disorder while on retinoid therapy should be referred to a neurologist. If the diagnosis is confirmed, the retinoid should be discontinued permanently.
Psychosis
Major:
isotretinoin
ISOtretinoin has a major potential interaction with Psychosis.
The use of retinoids, primarily isotretinoin, has been associated with causing depression, psychosis and rarely, suicidal ideation. Therapy with retinoids should be administered cautiously in patients with preexisting psychiatric conditions or depression. In addition to withdrawal of therapy, evaluation and follow-up may be necessary in affected patients.
Weight Loss
Moderate:
isotretinoin
ISOtretinoin has a moderate potential interaction with Weight Loss.
The use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.
More resources
BPO-5 Wash
A total of 11 drugs are known to interact with BPO-5 Wash.
- Bpo-5 wash is in the drug class topical acne agents.
- Bpo-5 wash is used to treat Acne.
isotretinoin
A total of 146 drugs are known to interact with isotretinoin.
- Isotretinoin is in the following drug classes: miscellaneous antineoplastics, miscellaneous uncategorized agents.
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Isotretinoin is used to treat the following conditions:
- Acne
- Acute Nonlymphocytic Leukemia (off-label)
- Granuloma Annulare (off-label)
- Melanoma, Metastatic (off-label)
- Pityriasis rubra pilaris (off-label)
- Rosacea (off-label)
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.