Drug Interactions between boceprevir and Premphase

Boceprevir may reduce the blood levels and effects of medroxyPROGESTERone, which may make it less reliable as a form of birth control. You may continue to use medroxyPROGESTERone if desired, but two alternative, non-hormonal methods of birth control should be used during and for two weeks after treatment with boceprevir to avoid unintended pregnancy. This is particularly important because one of the other hepatitis C medications that you must use, ribavirin, is known to cause major birth defects or even death in the unborn child. Examples of non-hormonal methods of birth control include: a male condom with spermicidal jelly OR a female condom with spermicidal jelly--a combination of a male condom and a female condom is not suitable; a diaphragm with spermicidal jelly; a cervical cap with spermicidal jelly; or an intrauterine device (IUD). Talk to your gynecologist or other healthcare professional for help in selecting effective methods of birth control that work best for you. If you take hormone replacement for menopause, you should contact your doctor if you experience increased frequency or worsening of your symptoms such as hot flashes, vaginal dryness, or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Boceprevir may increase the blood levels and effects of conjugated estrogens. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.