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Drug Interactions between boceprevir and Mycobutin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

rifabutin boceprevir

Applies to: Mycobutin (rifabutin) and boceprevir

GENERALLY AVOID: Coadministration of rifabutin with boceprevir or telaprevir is expected to increase the plasma concentrations of rifabutin and its metabolite and decrease the plasma concentrations of the hepatitis C virus NS3/4A protease inhibitor. The proposed mechanism involves inhibition of rifabutin metabolism via CYP450 3A4 and, conversely, induction of boceprevir and telaprevir metabolism via the same isoenzyme. The interaction has not been specifically studied with either boceprevir or telaprevir, but has been reported with HIV protease inhibitors, resulting in increased systemic exposure (AUC) of rifabutin by 100% to 300% and that of its 25-O-desacetyl metabolite by 13- to 35-fold. Uveitis secondary to rifabutin toxicity has been reported in some cases. The effect of rifabutin on HIV protease inhibitors may vary. Rifabutin had negligible effects on some protease inhibitors but reduced the AUC of others such as indinavir, nelfinavir, and saquinavir by 30% to nearly 50%.

MANAGEMENT: Safe and effective dosages have not been established for the concomitant use of rifabutin with either boceprevir or telaprevir. Coadministration is not recommended.

References

  1. (2011) "Product Information. Victrelis (boceprevir)." Schering-Plough Corporation
  2. (2011) "Product Information. Incivek (telaprevir)." Vertex Pharmaceuticals

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Drug and food interactions

Moderate

boceprevir food

Applies to: boceprevir

ADJUST DOSING INTERVAL: Food significantly enhances the oral bioavailability of boceprevir. When given at 800 mg three times daily with food, boceprevir exposure increased by up to 65% relative to administration in the fasting state. The bioavailability of boceprevir was similar regardless of meal type (e.g., high-fat versus low-fat) or whether taken 5 minutes prior to eating, during a meal, or immediately following completion of the meal. Therefore, boceprevir may be taken without regard to either meal type or timing of the meal.

MANAGEMENT: To ensure maximal oral absorption, boceprevir should be administered with a meal or light snack.

References

  1. (2011) "Product Information. Victrelis (boceprevir)." Schering-Plough Corporation

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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