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Drug Interactions between blinatumomab and vincristine

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

vinCRIStine blinatumomab

Applies to: vincristine and blinatumomab

MONITOR: Coadministration with blinatumomab may increase the plasma concentrations of drugs that are substrates of CYP450 isoenzymes. Initiation of blinatumomab treatment causes transient release of cytokines that may suppress CYP450 enzymes, although the potential for interaction has not been studied. Presumably, the highest drug-drug interaction risk would be during the first 9 days of the first cycle and the first 2 days of the second cycle.

MANAGEMENT: Caution is advised when blinatumomab is prescribed to patients receiving drugs that are metabolized by CYP450 isoenzymes, particularly those with a narrow therapeutic index such as carbamazepine, colchicine, cyclosporine, disopyramide, phenytoin, quinidine, theophylline, warfarin, macrolide immunosuppressants, vinca alkaloids, and some narcotic analgesics. Clinical and laboratory monitoring are recommended following the initiation of blinatumomab, and the individual dosage of the concomitant agents adjusted as needed.

References (1)
  1. (2014) "Product Information. Blincyto (blinatumomab)." Amgen USA

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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