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Drug Interactions between bleomycin and oxygen

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

bleomycin oxygen

Applies to: bleomycin and oxygen

ADJUST DOSE: The use of oxygen in patients undergoing bleomycin treatment may increase the severity of bleomycin-associated pulmonary toxicity. Severe and fatal respiratory distress syndrome, pneumonitis, and pulmonary fibrosis have been reported. The interaction may be dose-dependent. Oxygen concentrations higher then 30% may increase the risk of pulmonary toxicity. A study reported that the use of lower oxygen concentrations (22% to 30%) decreased the incidence of respiratory distress syndrome during surgery. The mechanism is unknown.

MANAGEMENT: The manufacturer considers the use of pulmonary function tests with 100% oxygen to be contraindicated in bleomycin-treated patients, and recommends the use of pulmonary function tests with less than 21% oxygen. During general anesthesia, it is recommended that bleomycin-treated patients receive oxygen concentrations less than 30%.

References (1)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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