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Drug Interactions between bivalirudin and lepirudin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

lepirudin bivalirudin

Applies to: lepirudin and bivalirudin

GENERALLY AVOID: The concomitant administration of bivalirudin and other anticoagulants may increase the risk of bleeding complications due to additive or synergistic effects on the clotting cascade. In clinical trials, the use of bivalirudin with heparin or warfarin in patients undergoing PTCA was associated with increased risks of major bleeding events. According to the manufacturer, results from drug interaction studies do not suggest pharmacodynamic interactions with low molecular weight heparin (LMWH). However, data are limited, and patients in clinical trials receiving LMWH were taken off the drug at least 8 hours prior to PTCA and administration of bivalirudin.

MANAGEMENT: Until further data are available, coadministration of bivalirudin and all anticoagulants should be undertaken with caution and only after thorough assessment of risks and benefits. Close clinical and laboratory observation for bleeding complications is recommended.

References (1)
  1. (2001) "Product Information. Angiomax (bivalirudin)." The Medicines Company

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.

Duplication

Anticoagulants

Therapeutic duplication

The recommended maximum number of medicines in the 'anticoagulants' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'anticoagulants' category:

  • bivalirudin
  • lepirudin

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer