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Drug Interactions between bimatoprost topical and dorzolamide / latanoprost / timolol ophthalmic

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

latanoprost ophthalmic bimatoprost topical ophthalmic

Applies to: dorzolamide / latanoprost / timolol ophthalmic and bimatoprost topical

MONITOR: In patients using bimatoprost or other prostaglandin analogs for the treatment of intraocular hypertension, the concomitant use of bimatoprost 0.03% ophthalmic solution to treat hypotrichosis of the eyelashes may interfere with the desired reduction in intraocular pressure (IOP). In clinical trials, bimatoprost 0.03% solution applied topically to the upper eyelid margin lowered IOP in both patients with or without elevated IOP, although the magnitude of the reduction was not cause for clinical concern. In previous studies of bimatoprost for the treatment of ocular hypertension, it has been shown that exposure of the eye to more than one dose of bimatoprost daily may decrease the IOP-lowering effect. Therefore, topical administration of bimatoprost to the eyelid in conjunction with ocular instillation of IOP-lowering prostaglandin analogs may decrease the IOP-lowering effect in ocular hypertensive patients.

MANAGEMENT: Patients using these products concomitantly should be closely monitored for changes to their intraocular pressure.

References (1)
  1. (2009) "Product Information. Latisse (bimatoprost topical ophthalmic)." Allergan Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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