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Drug Interactions between bilberry / evening primrose / flax and ezetimibe

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

flax ezetimibe

Applies to: bilberry / evening primrose / flax and ezetimibe

MONITOR: Concomitant use of flaxseed oil with ezetimibe may lead to lower plasma alpha-linolenic acid (ALA) levels. The mechanism may be related to ezetimibe-mediated inhibition of intestinal absorption of ALA contained in flaxseed oil. However, data for this interaction are conflicting. In one study, 34 cardiac disease patients were randomized into 4 groups for a 6-week trial of a daily dose of either: placebo, 10 mg ezetimibe, 2 g flaxseed oil (equivalent to 1 g ALA), or 10 mg ezetimibe with 2 g flaxseed oil. The flaxseed oil group presented a significant increase in ALA plasma levels of 6 mcg/dL, and the other groups showed a decrease in ALA plasma levels of 2 to 4 mcg/dL as compared to baseline. However, according to ezetimibe product labeling, preclinical studies showed no effects of ezetimibe on fatty acid absorption.

MANAGEMENT: Until further information is available, clinical or laboratory monitoring of the expected therapeutic benefits of flaxseed oil is recommended when ezetimibe is co-administered with flaxseed oil.

References (3)
  1. (2002) "Product Information. Zetia (ezetimibe)." Schering-Plough Corporation
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  3. Cerner Multum, Inc. "Australian Product Information."

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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