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Drug Interactions between betibeglogene autotemcel and Exjade

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

deferasirox betibeglogene autotemcel

Applies to: Exjade (deferasirox) and betibeglogene autotemcel

ADJUST DOSING INTERVAL: Iron chelators may decrease the effectiveness of betibeglogene autotemcel. The mechanism has not been established. Hematopoietic stem cell (HSC) mobilization followed by apheresis to obtain CD34+ cells is required for betibeglogene autotemcel manufacturing. Once the correct dose of betibeglogene autotemcel has been stored at the treatment facility and the availability of the back-up collection is confirmed, full myeloablative conditioning must be administered at least 48 hours before infusion of betibeglogene autotemcel. No data are currently available for this interaction.

MANAGEMENT: According to the manufacturer, iron chelators should be avoided for at least 7 days prior to initiation of myeloablative conditioning. After betibeglogene autotemcel infusion, use of myelosuppressive iron chelators should be avoided for 6 months. Non-myelosuppressive iron chelators may be considered if iron chelation is needed within 6 months after betibeglogene autotemcel infusion.

References (1)
  1. (2022) "Product Information. Zynteglo (betibeglogene autotemcel)." bluebird bio

Drug and food interactions

Moderate

deferasirox food

Applies to: Exjade (deferasirox)

ADJUST DOSING INTERVAL: According to product labeling, the bioavailability of deferasirox was variably increased when taken with a meal.

MANAGEMENT: To ensure consistent plasma drug levels, deferasirox should be taken on an empty stomach 30 minutes before eating preferably at the same time everyday.

References (1)
  1. (2005) "Product Information. Exjade (deferasirox)." Novartis Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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