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Drug Interactions between Bethkis and vancomycin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tobramycin vancomycin

Applies to: Bethkis (tobramycin) and vancomycin

MONITOR: When administered concomitantly, glycopeptide antibiotics and parenteral aminoglycosides or oral neomycin may have additive nephrotoxic or neurotoxic effects.

MANAGEMENT: If these drugs must be used together, renal function and serum drug concentrations should be monitored.

References (6)
  1. Odio C, McCracken GH, Nelson JD (1984) "Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children." J Pediatr, 105, p. 491-2
  2. Dean RP, Wagner DJ, Tolpin MD (1985) "Vancomycin/aminoglycoside nephrotoxicity." J Pediatr, 106, p. 861-2
  3. Sorrell TC, Collignon PJ (1985) "A prospective study of adverse reactions associated with vancomycin therapy." J Antimicrob Chemother, 16, p. 235-41
  4. Downs NJ, Neihart RE, Dolezal JM, Hodges GR (1989) "Mild nephrotoxicity associated with vancomycin use." Arch Intern Med, 149, p. 1777-81
  5. Pauly DJ, Musa DM, Lestico MR, Lindstrom MJ, Hetsko CM (1990) "Risk of nephrotoxicity with combination vancomycin-aminoglycoside antibiotic therapy." Pharmacotherapy, 10, p. 378-82
  6. Farber BF, Moellering RC Jr (1983) "Retrospective study of the toxicity of preparations of vancomycin from 1974 to 1981." Antimicrob Agents Chemother, 23, p. 138-41

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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