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Drug Interactions between Bethkis and carboplatin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

tobramycin CARBOplatin

Applies to: Bethkis (tobramycin) and carboplatin

GENERALLY AVOID: Combining carboplatin and aminoglycosides may increase the risk of nephro- and ototoxicity. The exact mechanism of the interaction is unknown. Both carboplatin and aminoglycosides have been reported to cause renal magnesium wasting.

MANAGEMENT: In patients currently receiving carboplatin therapy, the use of less toxic antimicrobials is preferable. If carboplatin and an aminoglycoside must be used together, renal function, auditory and vestibular function, and serum magnesium should be monitored carefully.

References (1)
  1. (2001) "Product Information. Paraplatin (carboplatin)." Bristol-Myers Squibb

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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