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Drug Interactions between beta-carotene and lutein

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

beta-carotene lutein

Applies to: beta-carotene and lutein

Coadministration of lutein and beta-carotene may alter the intestinal absorption of both compounds. The mechanism of interaction is unknown. In eight healthy volunteers administered lutein and beta-carotene simultaneously, the area under the serum concentration-time curve (AUC) of lutein was reduced by approximately 40% to 45% compared to control values, while beta-carotene AUC was reduced 35% to 69% in five subjects but increased 3- to 5-fold in three subjects. Lutein enhanced beta-carotene AUC only in subjects with low absorption of beta-carotene when administered alone. In another study, lutein was found to decrease the intestinal absorption of beta-carotene in 12 healthy male volunteers, whereas lycopene had no significant effects. The clinical significance of these changes has not been established.

References

  1. van den Berg H, van Vliet T "Effect of simultaneous, single oral doses of B-carotene with lutein or lycopene on the B-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men." Am J Clin Nutr 68 (1998): 82-9
  2. Kostic D, White WS, Olson JA "Intestinal absorption, serum clearance, and interactions between lutein and B-carotene when administered to human adults in separate or combined oral doses." Am J Clin Nutr 62 (1995): 604-10

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

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