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Can you take Berotralstat with Phlemex?

1 drug interaction and 2 additional warnings found for the following 2 drugs:

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Drug interactions

Moderate drug interactions

Moderate:

dextromethorphan berotralstat

Applies to: Phlemex (dextromethorphan / guaifenesin) and berotralstat

Berotralstat may increase the blood levels and effects of dextromethorphan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as difficulty breathing, dizziness, drowsiness, difficulty sleeping, or diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food/lifestyle interactions

Moderate food/lifestyle interactions

Moderate:

dextromethorphan Food/Lifestyle

Applies to: Phlemex (dextromethorphan / guaifenesin)

Alcohol can increase the nervous system side effects of dextromethorphan such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with dextromethorphan. Do not use more than the recommended dose of dextromethorphan, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Disease interactions

1 potential interaction Applies to: 1 condition, including Renal Dysfunction.

Renal Dysfunction

Moderate:

berotralstat

Berotralstat has a moderate potential interaction with Renal Dysfunction.

Berotralstat has not been studied in patients with end-stage renal disease (CrCl < 15 mL/min or patients requiring hemodialysis), and its use is not recommended in these patients. No dosage adjustment is recommended for patients with mild, moderate or severe renal impairment.

More resources

berotralstat

A total of 543 drugs are known to interact with berotralstat.

Phlemex

A total of 375 drugs are known to interact with Phlemex.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.