Can you take Berotralstat with Focinvez?
1 drug interaction and 2 additional warnings found for the following 2 drugs:
- berotralstat
- Focinvez (fosaprepitant)
Drug interactions
Moderate drug interactions
Moderate:
fosaprepitant berotralstat
Applies to: Focinvez (fosaprepitant) and berotralstat
Berotralstat may increase the blood levels and effects of fosaprepitant. This may increase the risk and/or severity of side effects of fosaprepitant such as headache, fatigue, diarrhea, and low numbers of certain blood cells. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as nausea, constipation, diarrhea, or loss of appetite. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease interactions
2 potential interactions Applies to: 2 conditions, including Liver Disease and Renal Dysfunction.
Liver Disease
Moderate:
Focinvez
The fosaprepitant in Focinvez has a moderate potential interaction with Liver Disease.
There are no clinical or pharmacokinetic data in patients with severe liver dysfunction (Child-Pugh score greater than 9); therefore, caution and additional monitoring for adverse reactions are recommended when using fosaprepitant in these patients.
Renal Dysfunction
Moderate:
berotralstat
Berotralstat has a moderate potential interaction with Renal Dysfunction.
Berotralstat has not been studied in patients with end-stage renal disease (CrCl < 15 mL/min or patients requiring hemodialysis), and its use is not recommended in these patients. No dosage adjustment is recommended for patients with mild, moderate or severe renal impairment.
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More resources
berotralstat
A total of 543 drugs are known to interact with berotralstat.
- Berotralstat is in the drug class hereditary angioedema agents.
- Berotralstat is used to treat Hereditary Angioedema.
Focinvez
A total of 471 drugs are known to interact with Focinvez.
- Focinvez is in the drug class NK1 receptor antagonists.
- Focinvez is used to treat Nausea/Vomiting, Chemotherapy Induced.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.