Can you take Benzocaine / cetylpyridinium topical with Dayvigo?
No drug interactions found, but 7 warnings to review for the following 2 drugs:
- benzocaine/cetylpyridinium topical
- Dayvigo (lemborexant)
Drug interactions
There were no interactions found between benzocaine / cetylpyridinium topical and Dayvigo. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:
lemborexant Food/Lifestyle
Applies to: Dayvigo (lemborexant)
Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with lemborexant unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of lemborexant. This may increase the risk of side effects such as central nervous system depression, abnormal sleep behaviors, worsening of depression or suicidal thoughts, changes in heartbeat, or headache. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactions Applies to: 6 conditions, including Depression, Liver Disease, Alcoholism, Methemoglobinemia, and G-6-PD Deficiency.
Alcoholism
Moderate:
Dayvigo
The lemborexant in Dayvigo has a moderate potential interaction with Alcoholism.
Patients treated with lemborexant should not consume alcohol as it can increase drowsiness and also the incidence of adverse effects.
Depression
Moderate:
Dayvigo
The lemborexant in Dayvigo has a moderate potential interaction with Depression.
Worsening of depression and suicidal thoughts and actions have been reported with the use of lemborexant. Caution is advised in patients with depression. Protective measures may be required in patients with suicidal tendencies, including prescription of the lowest number of tablets at one time.
G-6-PD Deficiency
Moderate:
benzocaine / cetylpyridinium topical
The benzocaine topical in benzocaine / cetylpyridinium topical has a moderate potential interaction with G-6-PD Deficiency.
Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.
Liver Disease
Moderate:
Dayvigo
The lemborexant in Dayvigo has a moderate potential interaction with Liver Disease.
Lemborexant has not been studied in patients with severe liver dysfunction (Child-Pugh Class C). Its use is not recommended in these patients.
Methemoglobinemia
Moderate:
benzocaine / cetylpyridinium topical
The benzocaine topical in benzocaine / cetylpyridinium topical has a moderate potential interaction with Methemoglobinemia.
Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.
Pulmonary Impairment
Moderate:
Dayvigo
The lemborexant in Dayvigo has a moderate potential interaction with Pulmonary Impairment.
Lemborexant has not been studied in patients with moderate to severe obstructive sleep apnea (OSA) or in patients with chronic obstructive pulmonary disease. Caution is advised if prescribing to patients with compromised respiratory function.
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More resources
benzocaine / cetylpyridinium topical
A total of 59 drugs are known to interact with benzocaine / cetylpyridinium topical.
- Benzocaine / cetylpyridinium topical is in the drug class mouth and throat products.
Dayvigo
A total of 491 drugs are known to interact with Dayvigo.
- Dayvigo is in the drug class miscellaneous anxiolytics, sedatives and hypnotics.
- Dayvigo is used to treat Insomnia.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.