Drug Interactions between benzgalantamine and omaveloxolone
This report displays the potential drug interactions for the following 2 drugs:
- benzgalantamine
- omaveloxolone
Interactions between your drugs
omaveloxolone benzgalantamine
Applies to: omaveloxolone and benzgalantamine
Consumer information for this interaction is not currently available.
MONITOR: Omaveloxolone may decrease the plasma concentrations of drugs that are substrates of CYP450 2C8 and/or 3A4 via induction of these isoenzymes. The systemic exposure (AUC) of repaglinide, a CYP450 2C8 substrate, decreased by approximately 35%, and the AUC of midazolam, a CYP450 3A4 substrate, decreased by approximately 45%, when administered with omaveloxolone. Reduced effectiveness of the substrates may result.
MANAGEMENT: The potential for diminished pharmacologic effects of CYP450 2C8 and/or 3A4 substrates should be considered during coadministration with omaveloxolone. The prescribing information for the substrates should be consulted for any dosage adjustments that may be required.
Drug and food interactions
omaveloxolone food
Applies to: omaveloxolone
Omaveloxolone should be taken on an empty stomach, at least one hour before eating. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with omaveloxolone unless directed otherwise by your doctor. Grapefruit juice may increase the blood levels of omaveloxolone. This may increase the risk of side effects such as changes in the amount of cholesterol in the blood and changes in liver and heart function tests. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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