Can you take Benzethonium chloride / lidocaine topical with Telaprevir?
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- benzethonium chloride/lidocaine topical
- telaprevir
Drug interactions
Moderate drug interactions
Moderate:
lidocaine topical telaprevir
Applies to: benzethonium chloride / lidocaine topical and telaprevir
Talk to your doctor before suing telaprevir together with lidocaine topical. Combining these medication may increase the blood levels and effects of lidocaine topical. This may increase the risk of side effects such as drowsiness, dizziness, trembling, numbness, slow heartbeat, or low blood pressure. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. There may be alternative medications that do not interact, or your doctor may recommend a dose adjustment or more frequent monitoring to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:
telaprevir Food/Lifestyle
Applies to: telaprevir
Food significantly increases the absorption of telaprevir. Within 30 minutes before you take each dose of telaprevir, you should eat a meal or snack containing approximately 20 grams of fat. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Examples of some foods that could be taken with telaprevir include: bagel with cream cheese; half cup of nuts; 3 tablespoons of peanut butter; 1 cup of ice cream; 2 ounces of American or cheddar cheese; 2 ounces of potato chips; or half cup of trail mix. Talk to your healthcare provider if you have additional questions about how to take telaprevir.
Minor food/lifestyle interactions
Minor:
lidocaine topical Food/Lifestyle
Applies to: benzethonium chloride / lidocaine topical
Information for this minor interaction is available on the professional version.
Disease interactions
6 potential interactions Applies to: 6 conditions, including Seizures, Liver Disease, Heart Block, Shock, and Renal Dysfunction.
Heart Block
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Heart Block.
Lidocaine is absorbed through intact skin and mucosal membranes following topical administration. Prolonged exposure, large doses, frequent applications and/or use on compromised skin or mucosa can produce systemic effects. At high plasma levels, lidocaine can cause hypotension, bradycardia, and cardiovascular collapse. Therapy with lidocaine topical should be administered cautiously in patients with shock, sinus bradyarrhythmia, or severe heart block. The recommended dosage should not be exceeded. Children and debilitated, elderly, or acutely ill patients should be given reduced dosages commensurate with their age, weight, and physical condition.
Liver Disease
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Liver Disease.
Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Lidocaine is rapidly and extensively metabolized by the liver. Less than 10% is eliminated unchanged in the urine. Several inactive and two active forms (MEGX and GX) have been identified. MEGX and GX exhibit antiarrhythmic and convulsant properties. The pharmacokinetic disposition of lidocaine is altered by changes in hepatic function, including hepatic blood flow. Therapy with lidocaine topical should be administered cautiously and dosing modified for patients with compromised hepatic function.
Renal Dysfunction
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Renal Dysfunction.
Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Lidocaine is primarily eliminated by the kidney. Less than 10% is eliminated unchanged in the urine. Two active metabolites (MEGX and GX) have been identified that exhibit antiarrhythmic and convulsant properties. Serum concentrations of lidocaine and the active metabolites are increased and the half-life prolonged in patients with renal impairment. Therapy with lidocaine topical should be administered cautiously and dosing modified for repeated doses in patients with compromised renal function.
Seizures
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Seizures.
Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Seizures can occur as a result of accumulation of active metabolites. Therapy with lidocaine topical should be administered cautiously to patients with or predisposed to seizure disorders.
Shock
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Shock.
Lidocaine is absorbed through intact skin and mucosal membranes following topical administration. Prolonged exposure, large doses, frequent applications and/or use on compromised skin or mucosa can produce systemic effects. At high plasma levels, lidocaine can cause hypotension, bradycardia, and cardiovascular collapse. Therapy with lidocaine topical should be administered cautiously in patients with shock, sinus bradyarrhythmia, or severe heart block. The recommended dosage should not be exceeded. Children and debilitated, elderly, or acutely ill patients should be given reduced dosages commensurate with their age, weight, and physical condition.
Teething Syndrome
Major:
benzethonium chloride / lidocaine topical
The lidocaine topical in benzethonium chloride / lidocaine topical has a major potential interaction with Teething Syndrome.
Topical lidocaine is not recommended to be used in teething infants and young children, as its ingestion is dangerous and potentially fatal. Ingestion of the drug has shown to result in seizures, severe brain injury, and heart problems in children.
Report options
More resources
benzethonium chloride / lidocaine topical
A total of 122 drugs are known to interact with benzethonium chloride / lidocaine topical.
- Benzethonium chloride / lidocaine topical is in the drug class miscellaneous topical agents.
telaprevir
A total of 507 drugs are known to interact with telaprevir.
- Telaprevir is in the drug class protease inhibitors.
- Telaprevir is used to treat Hepatitis C.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.