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Drug Interactions between Benemid and diflunisal

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

probenecid diflunisal

Applies to: Benemid (probenecid) and diflunisal

Probenecid may increase the pharmacologic and toxic effects of diflunisal in some patients by inhibition of hepatic metabolism and displacement from plasma protein-binding sites. Increased diflunisal concentrations may result. The clinical significance has not been reported. When these drugs are combined, patients should be observed for diflunisal toxicity such as nausea, vomiting, drowsiness, tinnitus, tachycardia, sweating, or confusion.

References (3)
  1. Diamond JS, Paolino JS (1973) "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest, 52, p. 1491-9
  2. Regal RE (1987) "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm, 21, p. 219-20
  3. Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK (1995) "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol, 47, p. 519-23

Drug and food/lifestyle interactions

Moderate

diflunisal food/lifestyle

Applies to: diflunisal

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References (1)
  1. (2002) "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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