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Drug Interactions between bempedoic acid and pravastatin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

pravastatin bempedoic acid

Applies to: pravastatin and bempedoic acid

ADJUST DOSE: Coadministration with bempedoic acid may increase the plasma concentrations of simvastatin and pravastatin and risk of statin-related myopathy. The mechanism of the interaction has not been reported. In one study, coadministration of bempedoic acid at steady-state with simvastatin resulted in approximately 2-fold and 1.5-fold increases in simvastatin systemic exposure (AUC) and peak plasma concentrations (Cmax), respectively. In another study, coadministration of bempedoic acid at steady-state with pravastatin resulted in 99% and 104% (2-fold each) increases in pravastatin AUC and Cmax, respectively.

MANAGEMENT: When coadministered with bempedoic acid the simvastatin dosage should not exceed 20 mg daily and the pravastatin dosage should not exceed 40 mg daily. Patients should be monitored for the development of statin-related myopathy. Some authorities consider concomitant use with simvastatin at doses greater than 40 mg daily to be contraindicated (UK). In addition, these same authorities consider coadministration of bempedoic acid with a statin contraindicated in patients with active liver disease or unexplained persistent elevations in serum transaminases.

References (3)
  1. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  2. (2020) "Product Information. Nexlizet (bempedoic acid-ezetimibe)." Esperion Therapeutics
  3. (2020) "Product Information. Nexletol (bempedoic acid)." Esperion Therapeutics

Drug and food interactions

Moderate

pravastatin food

Applies to: pravastatin

MONITOR: Concomitant use of statin medication with substantial quantities of alcohol may increase the risk of hepatic injury. Transient increases in serum transaminases have been reported with statin use and while these increases generally resolve or improve with continued therapy or a brief interruption in therapy, there have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins. Patients who consume substantial quantities of alcohol and/or have a history of liver disease may be at increased risk for hepatic injury. Active liver disease or unexplained transaminase elevations are contraindications to statin use.

MANAGEMENT: Patients should be counseled to avoid substantial quantities of alcohol in combination with statin medications and clinicians should be aware of the increased risk for hepatotoxicity in these patients.

References (9)
  1. (2001) "Product Information. Pravachol (pravastatin)." Bristol-Myers Squibb
  2. (2001) "Product Information. Zocor (simvastatin)." Merck & Co., Inc
  3. (2001) "Product Information. Lescol (fluvastatin)." Novartis Pharmaceuticals
  4. (2001) "Product Information. Lipitor (atorvastatin)." Parke-Davis
  5. (2002) "Product Information. Altocor (lovastatin)." Andrx Pharmaceuticals
  6. (2003) "Product Information. Crestor (rosuvastatin)." AstraZeneca Pharma Inc
  7. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  8. Cerner Multum, Inc. "Australian Product Information."
  9. (2010) "Product Information. Livalo (pitavastatin)." Kowa Pharmaceuticals America (formerly ProEthic)

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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