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Drug Interactions between bcg vaccine and hydrocortisone / lidocaine / psyllium topical

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

lidocaine topical BCG vaccine

Applies to: hydrocortisone / lidocaine / psyllium topical and bcg vaccine

Topical lidocaine has bactericidal and antiviral properties when used in concentrations above 0.5%. Clinical studies evaluating the impact of topical lidocaine on intradermal vaccinations are unavailable. However, the efficacy of live vaccines administered intradermally (e.g., BCG vaccine) may be diminished when used concomitantly with topical lidocaine formulations that are applied directly over the site of vaccine administration.

References (3)
  1. (2023) "Product Information. LMX 4 (lidocaine topical)." Ferndale Pharmaceuticals Ltd
  2. liu x, Zheng F, Tian L, li t, Zhang Z, Ren Z, Chen X, Chen W, li k, Sheng J (2023) "Lidocaine inhibits influenza a virus replication by up-regulating IFN-alpha4 via TBK1-IRF7 and JNK-AP1 signaling pathways" Int Immunopharmacol, 115, p. 1-9
  3. olsen km, Peddicord TE, Campbell GD, rupp me (2000) "Antimicrobial effects of lidocaine in bronchoalveolar lavage fluid" J Antimicrob Chemother, 45, p. 217-9

Drug and food interactions

Moderate

psyllium food

Applies to: hydrocortisone / lidocaine / psyllium topical

ADJUST DOSING INTERVAL: Bulk-forming laxatives such as guar gum, psyllium, polycarbophil, or methylcellulose may affect the bioavailability of concomitantly administered substances due to their effect on the rate of gastrointestinal transit and gastric emptying.

MANAGEMENT: In general, oral medications should be administered at least 2 hours before or 2 hours after dosing of the bulk-forming laxative.

References (1)
  1. (2001) "Product Information. Metamucil (psyllium)." Procter and Gamble Pharmaceuticals

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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