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Drug interactions between Bactrim and dapsone

Results for the following 2 drugs:
Bactrim (sulfamethoxazole/trimethoprim)

Interactions between your drugs


dapsone trimethoprim

Applies to: dapsone and Bactrim (sulfamethoxazole / trimethoprim)

Using dapsone together with trimethoprim may increase the risk and/or severity of side effects such as nausea, vomiting, abdominal pain, liver problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, and infections because of low blood cell counts. Of particular concern is the potential development of hemolysis, which is the premature destruction of red blood cells, and methemoglobinemia, a blood disorder that leads to impaired ability of red blood cells to distribute oxygen to tissues. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you develop headache, fatigue, dizziness, lightheadedness, fainting, shortness of breath, exercise intolerance, sore throat, fever, unusual bleeding or bruising, and paleness or a bluish discoloration of the skin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Drug and food interactions

No results found in our database - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Therapeutic duplication warnings

Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.


Antipneumocystis agents

Therapeutic duplication

The recommended maximum number of medicines in the 'antipneumocystis agents' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antipneumocystis agents' category:

  • Bactrim (sulfamethoxazole/trimethoprim)
  • dapsone

Note: The benefits of taking this combination of medicines may outweigh any risks associated with therapeutic duplication. This information does not take the place of talking to your doctor. Always check with your healthcare provider to determine if any adjustments to your medications are needed.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.