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Drug Interactions between bacitracin and cisatracurium

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

bacitracin cisatracurium

Applies to: bacitracin and cisatracurium

MONITOR: Like other polypeptide antibiotics, systemically administered bacitracin may prolong apnea and respiratory paralysis associated with the use of nondepolarizing neuromuscular blocking agents. The mechanism may involve decreased intracellular potassium or decreased ionized serum calcium, as intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.

MANAGEMENT: Patients should be closely monitored for prolonged or excessive neuromuscular blockade.

References (2)
  1. Kronenfeld MA, Thomas SJ, Turndorf H (1986) "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology, 65, p. 93-4
  2. Huang KC, Heise A, Shrader AK, Tsueda K (1990) "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg, 71, p. 194-6

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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