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Drug Interactions between azithromycin / trovafloxacin and nelfinavir

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

azithromycin nelfinavir

Applies to: azithromycin / trovafloxacin and nelfinavir

MONITOR: The concomitant administration of nelfinavir may significantly increase plasma concentrations of azithromycin. The mechanism is unknown. When single doses of azithromycin 1200 mg were given after nelfinavir 750 mg 3 times daily for 11 days, azithromycin area under the plasma concentration-time curve (AUC) and peak plasma concentrations (Cmax) increased by more than 2-fold. Nelfinavir AUC and Cmax decreased slightly.

MANAGEMENT: Close monitoring for azithromycin side effects such as hearing disturbances and liver enzyme elevations is recommended during concomitant administration.

References

  1. (2001) "Product Information. Viracept (nelfinavir)." Agouron Pharma Inc

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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