Drug Interactions between azithromycin / trovafloxacin and emtricitabine / nelfinavir / tenofovir
This report displays the potential drug interactions for the following 2 drugs:
- azithromycin/trovafloxacin
- emtricitabine/nelfinavir/tenofovir
Interactions between your drugs
azithromycin nelfinavir
Applies to: azithromycin / trovafloxacin and emtricitabine / nelfinavir / tenofovir
MONITOR: The concomitant administration of nelfinavir may significantly increase plasma concentrations of azithromycin. The mechanism is unknown. When single doses of azithromycin 1200 mg were given after nelfinavir 750 mg 3 times daily for 11 days, azithromycin area under the plasma concentration-time curve (AUC) and peak plasma concentrations (Cmax) increased by more than 2-fold. Nelfinavir AUC and Cmax decreased slightly.
MANAGEMENT: Close monitoring for azithromycin side effects such as hearing disturbances and liver enzyme elevations is recommended during concomitant administration.
References
- "Product Information. Viracept (nelfinavir)." Agouron Pharma Inc PROD (2001):
Drug and food interactions
tenofovir food
Applies to: emtricitabine / nelfinavir / tenofovir
Food enhances the oral absorption and bioavailability of tenofovir, the active entity of tenofovir disoproxil fumarate. According to the product labeling, administration of the drug following a high-fat meal increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of tenofovir by approximately 14% and 40%, respectively, compared to administration in the fasting state. However, administration with a light meal did not significantly affect the pharmacokinetics of tenofovir compared to administration in the fasting state. Food delays the time to reach tenofovir Cmax by approximately 1 hour. Tenofovir disoproxil fumarate may be administered without regard to meals.
References
- "Product Information. Viread (tenofovir)." Gilead Sciences (2001):
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.