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Drug Interactions between azathioprine and Cytoxan

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

azaTHIOprine cycloPHOSphamide

Applies to: azathioprine and Cytoxan (cyclophosphamide)

MONITOR: Concomitant administration of azathioprine and cyclophosphamide may cause hepatotoxicity, in some cases associated with hepatocellular necrosis. The mechanism is unknown. In addition, the risk of bone marrow suppression may be increased when azathioprine and cyclophosphamide are coadministered.

MANAGEMENT: If concomitant therapy is needed patients should be monitored for signs and symptoms of hepatotoxicity and myelotoxicity. Patients should be advised to promptly notify their physician if they experience fever, chills, sore throat, mouth sores, unusual fatigue, bleeding, bruising, abdominal pain, darkened urine, or pale stools.

References (1)
  1. Shaunak S, Munro JM, Weinbren K, Walport MJ, Cox TM (1988) "Cyclophosphamide-induced liver necrosis: a possible interaction with azathioprine." Q J Med, 67, p. 309-17

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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