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Drug Interactions between Ayvakit and bcg

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

BCG avapritinib

Applies to: bcg and Ayvakit (avapritinib)

If you are currently being treated or have recently been treated with avapritinib, you should let your doctor know before receiving BCG. Depending on the dose and length of time you have been on avapritinib, you may be at risk for developing an infection from BCG or have a reduced response to BCG. In some situations, your doctor may want to delay treatment with BCG to give your body time to recover from the effects of avapritinib therapy. Additionally, since the bacteria in BCG may persist in the urinary tract for months after treatment, you may still be at increased risk for infection even if you receive avapritinib after you have stopped treatment with BCG for some time. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drug and food interactions

Major

avapritinib food

Applies to: Ayvakit (avapritinib)

Avapritinib should be taken on an empty stomach, one hour before or two hours after a meal. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with avapritinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of avapritinib. This may increase the risk and/or severity of serious side effects such as bleeding in the brain; cognitive impairment (forgetfulness, confusion, trouble thinking); changes in mood or behavior; hallucinations; fluid retention or swelling; and decreases in blood cell counts. You may also be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer