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Drug Interactions between avibactam / aztreonam and probenecid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

probenecid avibactam

Applies to: probenecid and avibactam / aztreonam

GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of avibactam. The proposed mechanism is probenecid inhibition of OAT1 and OAT3 transporters, which may contribute to the active uptake of avibactam from the blood compartment for excretion. In vitro, probenecid has been reported to inhibit OAT uptake of avibactam by 56% to 70%. Therefore, probenecid has the potential to decrease the elimination of avibactam during coadministration.

MANAGEMENT: Due to a lack of clinical data, concomitant use of avibactam with probenecid is not recommended.

References (3)
  1. (2015) "Product Information. Avycaz (avibactam-ceftazidime)." Forest Pharmaceuticals
  2. (2024) "Product Information. Emblaveo (avibactam-aztreonam)." Pfizer Ltd, EB 1_2
  3. (2025) "Product Information. Emblaveo (avibactam-aztreonam)." AbbVie US LLC
Minor

probenecid aztreonam

Applies to: probenecid and avibactam / aztreonam

Coadministration of probenecid or furosemide with aztreonam results in clinically insignificant increases in aztreonam's systemic exposure. The proposed mechanism relates to inhibition of organic anion transporters 1 and 3 (OAT1, OAT3) by probenecid and furosemide, which may contribute to the active uptake of aztreonam from the blood compartment for excretion. The manufacturer does not recommend additional monitoring.

References (3)
  1. (2023) "Product Information. Azactam (aztreonam)." Bristol-Myers Squibb Pharmaceuticals Ltd
  2. (2022) "Product Information. Aztreonam (aztreonam)." Fresenius Kabi USA, LLC
  3. (2023) "Product Information. Azactam (aztreonam)." Bristol-Myers Squibb Australia Pty Ltd, 8

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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