Drug Interactions between Austedo XR and fluoxetine

FLUoxetine may increase the blood levels and effects of deutetrabenazine, such as sleepiness, abnormal involuntary muscle movements, and Parkinson-like symptoms such slight shaking, body stiffness, or trouble moving or keeping your balance, and an irregular heart rhythm problem called QT prolongation. Irregular heart rhythm problems may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any question or concerns. You may need a dose adjustment of deutetrabenazine before using these medications together. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, as well symptoms such as fever, heat intolerance, excessive sweating, stiff muscles, and difficulty moving or swallowing that do not have another obvious cause. Do not drive, operate heavy machinery, or do other dangerous activities until you know how this medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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