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Drug Interactions between Augmentin XR and sarecycline

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

amoxicillin sarecycline

Applies to: Augmentin XR (amoxicillin / clavulanate) and sarecycline

GENERALLY AVOID: Tetracyclines may reduce the effect of penicillins by inhibiting cellular protein synthesis which is necessary for cell wall synthesis inhibition by penicillins. Antagonism is more likely when low doses of either agent are administered. Therapeutic failure may result.

MANAGEMENT: This combination should be avoided if possible.

References (6)
  1. Gunnison JB, Coleman VR, Jawetz E (1950) "Interference of aureomycin and of terramycin with action of penicillin in vitro." Proc Soc Exp Biol Med, 75, p. 549-52
  2. Lepper MH, Dowling HF (1951) "Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin." Arch Intern Med, 88, p. 489-94
  3. Jawetz E (1975) "Synergism and antagonism among antimicrobial drugs: a personal perspective." West J Med, 123, p. 87-91
  4. Olsson RA, Kirby JC, Romansky MJ (1961) "Pneumococcal meningitis in the adult." Ann Intern Med, 55, p. 545-9
  5. (2001) "Product Information. Declomycin (demeclocycline)." Lederle Laboratories
  6. (2018) "Product Information. Seysara (sarecycline)." Allergan Inc

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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