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Drug Interactions between atazanavir and lazertinib

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

atazanavir lazertinib

Applies to: atazanavir and lazertinib

Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of lazertinib. To examine this interaction, healthy adult participants (n=16) received lazertinib (160 mg) on day 1, then the potent CYP450 3A4 inhibitor itraconazole (200 mg) daily on days 8 to 16. On day 12, the participants received another single dose of lazertinib (160 mg). Concomitant use of itraconazole increased lazertinib's peak plasma concentration (Cmax) and systemic exposure (AUC) by 1.2- and 1.5-fold, respectively. The clinical significance of these changes is unknown.

References (3)
  1. (2024) "Product Information. Lazcluze (lazertinib)." Janssen Biotech, Inc.
  2. Janssen Research & Development, LLC (2024) A study to assess the effects of itraconazole and rifampin on lazertinib in healthy adult participants. https://clinicaltrials.gov/study/NCT04410094?tab=table
  3. Mehta J, Haddish-Berhane N, Hellemans P, et al. (2024) PI-100-The drug-drug interaction (DDI) effect of steady state itraconazole exposure on single dose pharmacokinetics (PK) of lazertinib. https://ascpt2023.eventscribe.net/fsPopup.asp?efp=T0ZZRlFOUkgxODIxOQ&PosterID=553886&rnd=0.9604228&mode=posterInfo

Drug and food interactions

Moderate

atazanavir food

Applies to: atazanavir

ADJUST DOSING INTERVAL: Administration of atazanavir with food enhances oral bioavailability and reduces pharmacokinetic variability. According to the manufacturer, administration with a light meal increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of a single 400 mg dose of atazanavir by 57% and 70%, respectively, relative to the fasting state. Administration with a high-fat meal resulted in a mean increase of 35% in atazanavir AUC and no change in Cmax compared to fasting. The coefficient of variation of AUC and Cmax decreased by approximately one-half when given with either a light or high-fat meal compared to the fasting state.

MANAGEMENT: To ensure maximal oral absorption, atazanavir should be administered with or immediately after a meal.

References (1)
  1. (2003) "Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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