Drug Interactions between aspirin / omeprazole and plazomicin

Plazomicin can sometimes cause kidney damage, and using it with aspirin may increase that risk, particularly if the latter is used chronically for prolonged periods. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you experience some or all of these problems during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Chronic use of drugs known as proton pump inhibitors including omeprazole can sometimes cause hypomagnesemia (low blood levels of magnesium), and the risk may be further increased when combined with other medications that also have this effect such as plazomicin. In severe cases, hypomagnesemia can lead to irregular heart rhythm, palpitations, muscle spasm, tremor, and seizures. In children, abnormal heart rhythm may cause fatigue, upset stomach, dizziness, and lightheadedness. A dose adjustment or more frequent monitoring by the doctor may be required to safely use both medications. If you are using an over-the-counter proton pump inhibitor medication such as Prilosec OTC, Zegerid OTC or Prevacid 24 HR, you should follow the directions on the package carefully. Do not use the medication more frequently or for a longer period than recommended on the label unless otherwise prescribed by your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Information for this minor interaction is available on the professional version.