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Drug Interactions between ashwaganda and KIE

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

potassium iodide ashwagandha

Applies to: KIE (ephedrine / potassium iodide) and ashwaganda

MONITOR: Some research suggests the use of ashwagandha might affect thyroid function. In one study, three adult men who took 500 mg/day of a standardized ashwagandha extract for eight weeks had small increases in blood thyroxine (T4) levels. A small clinical trial with 50 participants with subclinical hypothyroidism found that ashwagandha, at 300 mg twice daily for eight weeks, lowered serum thyroid stimulating hormone (TSH) and increased triiodothyronine (T3) and T4 levels compared with placebo. These findings suggest that ashwagandha might interact with thyroid hormone therapy and antithyroid agents. The mechanism of interaction is not established.

MANAGEMENT: Clinical and laboratory monitoring of thyroid function may be necessary. The patient should be closely monitored for altered efficacy and safety while achieving a euthyroid state or when the thyroid hormone therapy or antithyroid agent dosage is added, discontinued, or changed.

References (6)
  1. (2024) "Product Information. Ashwagandha (ashwagandha)." Now Foods, 1
  2. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Office of Dietary Supplements Ashwagandha https://www.nccih.nih.gov/health/ashwagandha
  3. Panda S, Kar A (1998) "Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice" J Pharm Pharmacol, 50, p. 1065-1068
  4. Panda S, Kar A (1999) "Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice" J Pharm Pharmacol, 67, p. 233-239
  5. Gannon JM, Forrest PE, Roy Chengappa KN (2014) "Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder" J Ayurveda Integr Med, 5, p. 241-245
  6. sharma ak, Basu l, Singh S (2018) "Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial" J Altern Complement Med, 24, p. 243-248

Drug and food interactions

Moderate

ePHEDrine food

Applies to: KIE (ephedrine / potassium iodide)

MONITOR: Coadministration of two or more sympathomimetic agents may increase the risk of adverse effects such as nervousness, irritability, and increased heart rate. Central nervous system (CNS) stimulants, particularly amphetamines, can potentiate the adrenergic response to vasopressors and other sympathomimetic agents. Additive increases in blood pressure and heart rate may occur due to enhanced peripheral sympathetic activity.

MANAGEMENT: Caution is advised if two or more sympathomimetic agents are coadministered. Pulse and blood pressure should be closely monitored.

References (7)
  1. Rosenblatt JE, Lake CR, van Kammen DP, Ziegler MG, Bunney WE Jr (1979) "Interactions of amphetamine, pimozide, and lithium on plasma norepineophrine and dopamine-beta-hydroxylase in schizophrenic patients." Psychiatry Res, 1, p. 45-52
  2. Cavanaugh JH, Griffith JD, Oates JA (1970) "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther, 11, p. 656
  3. (2001) "Product Information. Adderall (amphetamine-dextroamphetamine)." Shire Richwood Pharmaceutical Company Inc
  4. (2001) "Product Information. Tenuate (diethylpropion)." Aventis Pharmaceuticals
  5. (2001) "Product Information. Sanorex (mazindol)." Novartis Pharmaceuticals
  6. (2001) "Product Information. Focalin (dexmethylphenidate)." Mikart Inc
  7. (2002) "Product Information. Strattera (atomoxetine)." Lilly, Eli and Company

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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