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Drug Interactions between ashwaganda and i3odine Max

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

sodium iodide I-131 ashwagandha

Applies to: i3odine Max (sodium iodide-i-131) and ashwaganda

MONITOR: Some research suggests the use of ashwagandha might affect thyroid function. In one study, three adult men who took 500 mg/day of a standardized ashwagandha extract for eight weeks had small increases in blood thyroxine (T4) levels. A small clinical trial with 50 participants with subclinical hypothyroidism found that ashwagandha, at 300 mg twice daily for eight weeks, lowered serum thyroid stimulating hormone (TSH) and increased triiodothyronine (T3) and T4 levels compared with placebo. These findings suggest that ashwagandha might interact with thyroid hormone therapy and antithyroid agents. The mechanism of interaction is not established.

MANAGEMENT: Clinical and laboratory monitoring of thyroid function may be necessary. The patient should be closely monitored for altered efficacy and safety while achieving a euthyroid state or when the thyroid hormone therapy or antithyroid agent dosage is added, discontinued, or changed.

References (6)
  1. (2024) "Product Information. Ashwagandha (ashwagandha)." Now Foods, 1
  2. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Office of Dietary Supplements Ashwagandha https://www.nccih.nih.gov/health/ashwagandha
  3. Panda S, Kar A (1998) "Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice" J Pharm Pharmacol, 50, p. 1065-1068
  4. Panda S, Kar A (1999) "Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice" J Pharm Pharmacol, 67, p. 233-239
  5. Gannon JM, Forrest PE, Roy Chengappa KN (2014) "Subtle changes in thyroid indices during a placebo-controlled study of an extract of Withania somnifera in persons with bipolar disorder" J Ayurveda Integr Med, 5, p. 241-245
  6. sharma ak, Basu l, Singh S (2018) "Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial" J Altern Complement Med, 24, p. 243-248

Drug and food interactions

Moderate

sodium iodide I-131 food

Applies to: i3odine Max (sodium iodide-i-131)

MONITOR: Excessive intake of dietary iodine (e.g., iodised salt) may interfere with adequate uptake of radioiodide by the thyroid .

MANAGEMENT: A diet low in iodine is recommended before initiating therapy with sodium iodide I-131 or I-123.

References (1)
  1. Cerner Multum, Inc. "Australian Product Information."
Moderate

sodium iodide I-131 food

Applies to: i3odine Max (sodium iodide-i-131)

ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.

MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.

References (1)
  1. (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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