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Drug Interactions between Aristopak and desmopressin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

desmopressin triamcinolone

Applies to: desmopressin and Aristopak (triamcinolone)

CONTRAINDICATED: Coadministration of desmopressin with loop diuretics or systemic or inhaled corticosteroids may increase the risk of severe hyponatremia. Loop diuretics and corticosteroids can potentiate the antidiuretic response to desmopressin by causing loss of sodium and water retention, respectively, thus coadministration may increase the risk of water intoxication and hyponatremia. Elderly patients may be particularly susceptible.

MANAGEMENT: Concomitant use of certain desmopressin products with loop diuretics or systemic or inhaled corticosteroids is considered contraindicated. Please consult individual product labeling for specific recommendations. Caution is advised when coadministration is required. Serum electrolytes, especially sodium, as well as BUN and creatinine should be monitored regularly and as often as clinically appropriate based on individual risk factors. Patients should be advised to seek medical attention if they develop signs and symptoms of water intoxication or hyponatremia such as anorexia, nausea, vomiting, headache, malaise, lethargy, irritability, difficulty concentrating, memory impairment, confusion, weakness, muscle spasm, unsteadiness (which may lead to falls), anuria, and weight gain. Severe hyponatremia can be life-threatening if it is not promptly diagnosed and treated; therefore, early treatment is important to help prevent progression to seizures, coma, respiratory arrest, and death.

References

  1. "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer PROD (2001):
  2. "Product Information. Stimate (desmopressin)." Forest Pharmaceuticals PROD (2001):
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. Cerner Multum, Inc. "Australian Product Information." O 0
  5. "Product Information. Noctiva (desmopressin)." Avadel Pharmaceuticals (2018):
  6. "Product Information. Nocdurna (desmopressin)." Ferring Inc (2018):
View all 6 references

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Drug and food interactions

Minor

desmopressin food

Applies to: desmopressin

Food may decrease the rate and extent of absorption of desmopressin following oral administration. In 16 healthy, nonsmoking volunteers, administration of a single 400 mcg oral dose of desmopressin concomitantly with a standardized meal (27% fat) resulted in a 52% decrease in the peak plasma concentration (Cmax) of desmopressin and a 43% decrease in systemic exposure (AUC) compared to administration in the fasting state. The Cmax and AUC were still reduced by 46% and 41%, respectively, when desmopressin was administered 1.5 hours after eating. Both feeding regimens prolonged the time to reach peak plasma concentration (Tmax) from 1 hour to 1.5 hours. However, the pharmacodynamic effects of desmopressin were not affected as assessed by urine volume and osmolality for at least 4 hours postdose. The degree of antidiuresis was similar in the absence of food and when the drug was taken with or 1.5 hours after eating. These findings would suggest a fairly minor clinical impact of the interaction in most patients, especially since oral desmopressin is intended for administration at bedtime. Nevertheless, the possibility of food effects should be considered before increasing the dose whenever a diminution of effect is noted. A significant interaction is not expected to occur with the sublingual formulation, since absorption occurs primarily in the oral mucosa, pharynx, and esophagus.

References

  1. "Product Information. DDAVP (desmopressin)." Rhone Poulenc Rorer PROD (2001):
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Canadian Pharmacists Association "e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink" (2006):

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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