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Drug Interactions between Arduan and Hydeltra-TBA

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

prednisoLONE pipecuronium

Applies to: Hydeltra-TBA (prednisolone) and Arduan (pipecuronium)

MONITOR: Corticosteroids may inhibit or enhance the action of nondepolarizing skeletal muscle relaxants. The mechanism is unknown. In addition, the risk of myopathy may be increased after long-term use of neuromuscular blocking agents and corticosteroids.

MANAGEMENT: Patients should be closely monitored for altered neuromuscular blockade and signs of myopathy. Dose adjustments of the muscle relaxant may be required. The benefit-to-risk ratio should be considered and the duration of administration of the neuromuscular blocking agent should be limited as much as clinically feasible.

References

  1. Parr SM, Galletly DC, Robinson BJ "Betamethasone-induced resistance to vercuronium: a potential problem in neurosurgery." Anaesth Intensive Care 19 (1991): 103-5
  2. Laflin MJ "Interaction of pancuronium and corticosteroids." Anesthesiology 47 (1977): 471-2
  3. Meyers EF "Partial recovery from pancuronium neuromuscular blockade following hydrocortosone administration." Anesthesiology 46 (1977): 148-50
  4. "Product Information. Zemuron (rocuronium)." Organon PROD (2001):
  5. "Product Information. Norcuron (vecuronium)." Organon PROD (2001):
  6. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  7. Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html" (2008):
  8. "Product Information. Betamethasone Acet-Betamethasone Na Phos (betamethasone)." Exela Pharma (2022):
View all 8 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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