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Drug Interactions between Arava and Singulair

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

montelukast leflunomide

Applies to: Singulair (montelukast) and Arava (leflunomide)

Leflunomide may increase the blood levels and effects of montelukast. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as headache, fever, sore throat, cough, abdominal pain, diarrhea, earache, runny nose, or uncommon but serious behavior and mood changes (e.G., agitation including aggressive behavior or hostility; bad or vivid dreams; depression; confusion; difficulty concentrating; anxiety; hallucinations; irritability; memory impairment; restlessness; sleep walking; suicidal thoughts and actions; tremor; trouble sleeping). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

leflunomide food

Applies to: Arava (leflunomide)

Leflunomide can be taken with or without food. It is important to take leflunomide regularly to get the most benefit. Discuss with your doctor the use of alcohol while taking leflunomide. Alcohol and leflunomide can both be damaging to the liver.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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