Drug Interactions between apixaban and heparin flush

Using heparin flush together with apixaban may increase the risk of bleeding. Although heparin flush is generally given in low concentrations to help keep IV catheters open and flowing freely by preventing blood clots, small amounts of heparin may get into the blood stream. Following repeated or excessive use, heparin can accumulate and cause bleeding complications, especially when used with other medications that can also impair clotting or cause low platelet counts. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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