Drug Interactions between Antrocol and mebendazole
This report displays the potential drug interactions for the following 2 drugs:
- Antrocol (atropine/phenobarbital)
- mebendazole
Interactions between your drugs
mebendazole PHENobarbital
Applies to: mebendazole and Antrocol (atropine / phenobarbital)
MONITOR: Coadministration with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may decrease mebendazole levels. The mechanism is unknown, but induction of hepatic metabolism by these anticonvulsant drugs has been proposed. A study of 17 patients on high dose, long-term (over 18 months) oral mebendazole therapy for hydatid disease describes a reduction in serum mebendazole concentrations that was attributed to concomitant carbamazepine or phenytoin therapy. However, since plasma mebendazole levels varied greatly among patients in the study, and each patient had only a single measurement of plasma mebendazole, the clinical significance of the purported pharmacokinetic interaction cannot be fully determined. Clinical impact is expected to be minimal in the treatment of intestinal infections, but may be increased when mebendazole is used for helminthic diseases in tissues beyond the GI tract.
MANAGEMENT: Caution and monitoring for altered clinical efficacy are recommended if mebendazole is used concomitantly with anticonvulsant drugs such as carbamazepine, phenytoin, phenobarbital, or primidone in patients being treated for systemic helminthic infections. Dose adjustments or alternative treatments may be required if an interaction is suspected.
References
- Bekhti A, Pirotte J, Woestenborghs R (1986) "A correlation between serum mebendazole concentrations and the aminopyrine breath test: implications in the treatment of hyatid disease." Br J Clin Pharmacol, 21, p. 223-6
- Luder PJ, Siffert B, Witassek F, Meister F, Bircher J (1986) "Treatment of hydatid disease with high oral doses of membendazole." Eur J Clin Pharmacol, 31, p. 443-8
- Romo ML, Carpio A, Kelvin EA (2014) "Routine drug and food interactions during antihelminthic treatment of neurocysticercosis: a reason for the variable efficacy of albendazole and praziquantel?" J Clin Pharmacol, 54, p. 361-7
- Pawluk SA, Roels CA, Wilby KJ, Ensom MHH (2015) "A review of pharmacokinetic drug–drug interactions with the anthelmintic medications albendazole and mebendazole." Clin Pharmacokinet, 54, p. 371-83
Drug and food interactions
PHENobarbital food
Applies to: Antrocol (atropine / phenobarbital)
GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.
MANAGEMENT: The combination of ethanol and barbiturates should be avoided.
References
- Gupta RC, Kofoed J (1966) "Toxological statistics for barbiturates, other sedatives, and tranquilizers in Ontario: a 10-year survey." Can Med Assoc J, 94, p. 863-5
- Misra PS, Lefevre A, Ishii H, Rubin E, Lieber CS (1971) "Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats." Am J Med, 51, p. 346-51
- Saario I, Linnoila M (1976) "Effect of subacute treatment with hypnotics, alone or in combination with alcohol, on psychomotor skills related to driving." Acta Pharmacol Toxicol (Copenh), 38, p. 382-92
- Stead AH, Moffat AC (1983) "Quantification of the interaction between barbiturates and alcohol and interpretation of fatal blood concentrations." Hum Toxicol, 2, p. 5-14
- Seixas FA (1979) "Drug/alcohol interactions: avert potential dangers." Geriatrics, 34, p. 89-102
atropine food
Applies to: Antrocol (atropine / phenobarbital)
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References
- Linnoila M (1973) "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol, 6, p. 107-12
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
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