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Drug Interactions between Anectine and colistimethate

This report displays the potential drug interactions for the following 2 drugs:

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Major

succinylcholine colistimethate

Applies to: Anectine (succinylcholine) and colistimethate

MONITOR CLOSELY: Like other polypeptide antibiotics, colistimethate may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium.

MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.

References

  1. Kronenfeld MA, Thomas SJ, Turndorf H (1986) "Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation." Anesthesiology, 65, p. 93-4
  2. Huang KC, Heise A, Shrader AK, Tsueda K (1990) "Vancomycin enhances the neuromuscular blockade of vecuronium." Anesth Analg, 71, p. 194-6
  3. (2001) "Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics."
  5. Cerner Multum, Inc. "Australian Product Information."
  6. Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
  7. Cerner Multum, Inc. (2015) "Canadian Product Information."
  8. Cerner Multum, Inc (2015) "ANVISA Bulário Eletrônico."
  9. (2019) "Product Information. Rocuronium Bromide (rocuronium)." Hospira Inc
  10. (2019) "Product Information. Vecuronium Bromide (vecuronium)." Hospira Inc
View all 10 references

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Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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