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Drug Interactions between Anaflex and niacin

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Minor

niacin salsalate

Applies to: niacin and Anaflex (salsalate)

Salicylates may cause an elevation in serum levels of nicotinic acid. The mechanism is not completely understood. However, salicylates also significantly decrease the serum levels of nicotinuric acid--a metabolite--and some experts hypothesize that salicylic acid causes a concentration-dependent decrease in the total clearance of nicotinic acid. Such a decrease would result in the saturation of the nicotinuric acid conjugation pathway. Data are available for aspirin only. No special precautions appear to be necessary.

References

  1. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ "Pharmacokinetics of nicotinic acid-salicylic acid interaction." Clin Pharmacol Ther 46 (1989): 642-7

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Drug and food interactions

Moderate

niacin food

Applies to: niacin

GENERALLY AVOID: Ethanol can exacerbate the cutaneous flushing that is a common side effect of niacin. At least one case of delirium and lactic acidosis has been reported with coadministration of these drugs, although data are limited.

MANAGEMENT: Coadministration should probably be discouraged, particularly since chronic consumption of large amounts of alcohol is associated with hyperlipidemia.

References

  1. Schwab RA, Bachhuber BH "Delirium and lactic acidosis caused by ethanol and niacin coingestion." Am J Emerg Med 9 (1991): 363-5

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Moderate

salsalate food

Applies to: Anaflex (salsalate)

GENERALLY AVOID: The concurrent use of aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) and ethanol may lead to gastrointestinal (GI) blood loss. The mechanism may be due to a combined local effect as well as inhibition of prostaglandins leading to decreased integrity of the GI lining.

MANAGEMENT: Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):

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Minor

niacin food

Applies to: niacin

A single case has been reported in which cutaneous flushing and tremors were noted in a woman who was taking niacin while wearing a nicotine patch. The mechanism is suspected to be synergistic cutaneous vasodilatory effects. The clinical significance of this possible interaction is not known.

References

  1. Rockwell KA Jr "Potential interaction between niacin and transdermal nicotine." Ann Pharmacother 27 (1993): 1283-8

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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